Skip to main content


Cyclotron and linear accelerator generated scanning proton beams for lung cancer SBRT: Interplay effects and mitigations by Dr. Jonathan Farr and Dr. Anna Kolano

30 April 2024

The purpose of this research article is to evaluate the impact of different types of PBS proton accelerators and spot sizes on interplay effects, mitigations, and plan quality for Stereotactic Body Radiation Therapy (SBRT) treatment of non-small cell lung cancer (NSCLC).

Advanced Oncotherapy PLC demonstrates the potential superiority of LIGHT in treating breast cancer patients

30 November 2022

Dr Jonathan Farr DSc, Chief Clinical Officer of Advanced Oncotherapy plc, presents the results of a recent study undertaken with partners the Cleveland Clinic, which demonstrates the potential advantages of treating breast cancer with the LIGHT system, when compared to conventional cyclotrons. The study demonstrates that LIGHT proton minibeams could result in up to 99% reduction in radiation dose to critical organs, the heart and lungs, compared with cyclotron-generated protons.

230 MeV Maximum Energy Achieved

11 October 2022

On 26th September 2022 Advanced Oncotherapy reached a critical milestone in our journey in bringing a new linear accelerator proton treatment system to the market - the acceleration of the proton beam up to maximum system energy of 230 MeV.

The advanced LIGHT conformal scanned FLASH capability is favourably compared to cyclotron passive FLASH

15 June 2022

Dr. Jonathan Farr, Chief Clinical Officer of Advanced Oncotherapy recently presented to the global medical physics and biomedical engineering community at IUPESM World Congress in Singapore. His presentation entitled “Ultra-High Dose Rate Production and Delivery Systems Intended for Flash”.

Advanced Oncotherapy PLC on its proton beam therapy system

13 May 2022

Dr. Jonathan Farr, Chief Clinical Officer of Advanced Oncotherapy interviewed with ProactiveInvestors to talk about the company's LIGHT, proton beam therapy system.

Top 10 Impactful Healthcare Leaders to Watch in 2022: Interview with Beyond Exclamation Magazine

10 May 2022

Nicolas Serandour, CEO of Advanced Oncotherapy is featured in the top 10 impactful healthcare leaders to watch in 2022. See his story on page 20 and his vision to democratise proton therapy.


31 March 2022

Nicolas Serandour, CEO of Advanced Oncotherapy, interviewed with Proactive investors to discuss about democratising Proton Beam Therapy and provides an update on the development of the LIGHT system.

Study shows potential of Advanced Oncotherapy’s LIGHT proton therapy for resistant cancers

19 March 2021

Advanced Oncotherapy plc reported new findings demonstrating the potential ability and superiority of its next-generation proton therapy system, LIGHT, to treat resistant cancers. The findings build on research at the Mayo Clinic that highlighted the benefits of combining proton therapy (PT) with targeted small molecule damage repair inhibitors.

UK Investormagazine Podcast

12 February 2021

The UK Investor Magazine Podcast was joined by Nicolas Serandour, CEO of Advanced Oncotherapy, to discuss the latest progress in democratising Proton Beam Therapy.

Investigation on the PBS FLASH Beam Delivery Technique Using a Proton Linac by Dr. Jonathan Farr and Dr. Anna Kolano

25 October 2020

This study aims to investigate the use of proton Pencil Beam Scanning (PBS) for uniform FLASH irradiations in clinical and (radio)biology settings using a pulsed proton therapy Linac and to report on PBS FLASH beam delivery possibilities and limitations.

Proton LINAC Transverse Beam Scanning Performance Implications for Therapeutic Quality Improvement by Dr. Jonathan Farr and Dr. Anna Kolano

25 October 2020

The purpose of the study is to determine which clinical indications benefit most and by how much from minimizing and holding a proton scanning spot size constant over the range 150-230 MeV in comparison to existing systems and techniques.

Investor Day Update

19 October 2020

Advanced Oncotherapy held its Investor Day presentation on 19 October 2020. A recording of the presentation and of the full Q&A is available on the Investor Meet Company platform.

Advanced Oncotherapy progresses towards ‘democratising proton therapy’ by UK Investor Magazine

02 October 2020

Advanced Oncotherapy (AIM:AVO), developer of proton therapy systems for cancer treatment, recently announced several areas of progress which will help realise its goal of ‘democratising proton therapy’.


23 September 2020

Euan S. Thomson, PhD., Global President Ophthalmic Devices and Head of Digital Business Unit for Carl Zeiss Meditec, and Medical Advisor to Advanced Oncotherapy plc, shares his views on the future of data sharing for proton therapy and for Advanced Oncotherapy plc in particular. Treatment planning for proton therapy is complex and requires a number of steps to achieve the desired dose distributions. Without a national or international strategy to coordinate unified treatment protocols, patients treated with protons have been managed with several delivery modalities, treatment paradigms and fractionation schemes. A key area for optimising the treatment planning process is therefore in gaining experience by encouraging all centres to share treatment plans with each other, retrospectively and in real time. To facilitate this process, Advanced Oncotherapy is working on treatment planning software to be hosted on the cloud.

Immunotherapy and PBT

24 July 2020

The combination of proton therapy with immunotherapy is considered promising and has gained substantial interest over the last 2 years. According to Prof Justin Stebbing, an internationally acclaimed expert in immunotherapies for cancer, “the synergies between immunotherapy and radiotherapy can potentially allow for better treatment of cancers, improving both quality and quantity of life.” A recent paper published in the British Journal of Radiology shows that proton therapy might be better adapted to for combination with immunotherapy because it causes less damage to the immune cells and induces a stronger immune response due to a different cell death mechanism.

Ahead of the ASTRO conference in October

25 June 2020

FLASH continues to prove its unique advantages in healthy tissue sparing with tumour control even in radioresistant cases. The LIGHT system is uniquely suited to application of FLASH at all depths. Currently we are investigating the delivery FLASH dose rates for a wide range of spot sizes. Follow us at upcoming ASTRO for more details!

New paths to proton therapy

30 April 2020

On page 83-85 of Healthcare in London magazine, CEO of Advanced Oncotherapy plc, Nicolas Serandour provides an update on the development of the LIGHT system.

Nicolas Serandour's interview with London Suisse Luxe Magazine

09 March 2020

Nicolas Serandour is CEO of Advanced Oncotherapy plc, a company not only at the forefront of developing a new proton beam therapy system, but also at the heart of a move to make this treatment available to people who would never normally have access to it.

Prognosis magazine interviewed Michael Sinclair, executive chairman of Advanced Oncotherapy

27 February 2020

On bringing proton beam therapy, a revolutionary new cancer treatment, to Harley Street

A Win for Protons in Pediatric Brain Tumors

23 December 2019

New data supporting the benefit of proton therapy is continuously emerging. See what Medpage says about proton therapy for paediatric brain tumours.

Advanced Oncotherapy readies first linear proton beam accelerator system for debut

09 December 2019

Advanced Oncotherapy plc is starting verification and validation of the world’s first linear proton beam accelerator system, which is assembled and ready for testing at the Daresbury particle physics laboratory in Cheshire, U.K.

Advanced Oncotherapy PLC: Q&A with The Howard de Walden Estate

23 September 2019

Building work at 141-143 Harley Street, the site of Advanced Oncotherapy’s first proposed commercial installation of LIGHT, has been recently completed. The Company just announced handover ahead of the fit-out process. Below is a Q&A with Simon Baynham, the property director at The Howard de Walden Estate, the landlord and developer of the Harley Street Medical Area.

PBT will become as common as MRI scanning

09 August 2019

Because our LIGHT system has been designed to significantly reduce the treatment cost of patient and it can be installed in small to mid-size health care centres throughout the country, every patient ought to benefit from a proton therapy centre in their vicinity which is expected to drive patients’ demand for this treatment.

Advanced Oncotherapy: Democratising proton beam therapy

08 July 2019

Check out the interview granted by Moataz Karmalawy, President of US division and Chief Commercial Officer of Advanced Oncotherapy.

FT: UK biotechs seek to speed up cancer detection

07 June 2019

Nicolas Serandour speaks to Sarah Neville about how LIGHT's streamlined design is going to help to bridge the gap between resources and demand, and “democratise” proton beam therapy, a treatment that can make a difference.

The Times: Proton beams ‘better at treating brain tumours’.

02 June 2019

The news could scarcely have been better for Harry Muldowney, a 10-year-old Herefordshire schoolboy with a brain tumour. Last month he became one of the first NHS patients to begin a potentially life-saving course of proton beam therapy, a pioneering cancer treatment.

Accelerating Innovation through International Collaboration

22 March 2019

Prof Steve Myers, Executive Chair ADAM and former Director of Accelerators at CERN, was in Liverpool to talk about ‘Accelerating Innovation through International Collaboration’.

Girl, 9, survives inoperable cancer after proton beam therapy

20 March 2019

The front page of the Times features the story of how Caroline, a 9-year-old British girl diagnosed with a rare inoperable cancer known as a rhabdomyosarcoma, has made a full recovery thanks to proton beam therapy. Also available on StoryTrender

A Meyrin, on dessine la firme de demain

09 February 2019

[Article in French] Listed on the London Stock Exchange, Advanced Oncotherapy believes it has discovered a real vein: the development of a new system focused on proton therapy. This promising technology fights cancer.

AVO's linear proton accelerator LIGHT showcased on Japanese TV

23 November 2018

In October 2018, NHK World TV visited the ADAM bunker facility in Geneva and interviewed ADAM Chairman, Former CERN Director of Accelerators and Technology, Prof. Stephen Myers OBE.

Effect of radiation exposure in brain tumours on hormone deficiencies

21 August 2018

This article in the Journal of Clinical Oncology provides strong support for the benefits of advanced radiation technologies such as proton therapy for the treatment of brain tumours, especially in younger patients.

AVO’s CEO Nicolas Serandour: Proton therapy is going to become a reality for every cancer patient

08 August 2018

AVO’s CEO Nicolas Serandour explains how the LIGHT system will significantly decrease the costs of proton therapy and allow to treat more kinds of cancer. “Proton therapy is going to become a reality for every cancer patient” - says Serandour

Proton therapy goes slimline-Manufacturers are reducing the size of proton-therapy systems to better compete with traditional radiotherapy

01 August 2018

Physics World reports - Physics World reports on advances in proton therapy technology. Our LIGHT system is also discussed.

LIGHT was discussed at the first International Symposium on the Next Generation of Hadron Therapy in Tsukuba, Japan

09 July 2018

CERN Courier - "The first model of LIGHT, a linac-based hadron-therapy system that operates at [200 Hz] with an energy sweep, and which is going to be installed at Harley Street, London" was discussed at the first International Symposium on the Next Generation of Hadron Therapy in Tsukuba, Japan. See the article in the last edition of the CERN Courier.

Beams of Life | Mega | in conversation with Stephen Myers

23 May 2018

Proton therapy is a new way of beating cancer, with fewer side effects than conventional radiation treatments, explains Stephen Myers a pioneering nuclear medicine scientist.

All About Proton Therapy

01 February 2018

Carolyn Vachani (University of Pennsylvania) - - This article compares various radiation oncology techniques.

Therapeutic particles

01 January 2018

Virginia Greco (CERN) - CERN Courier - The history of proton therapy.

Huge leap in prostate cancer testing

01 January 2018

BBC news

Advanced Oncotherapy gets boost from stalwart investor

10 December 2017

by Financial Times, Kate Burgess

AVO is fortunate to have investor stalwarts at its back

10 December 2017

Financial Times - Investors trust, that the LIGHT system is the future of proton therapy.

Three ways to make proton therapy affordable

01 September 2017

Thomas Bortfeld & Jay Loeffler (Mass. Gen. Hospital, Harvard Medical School) - Nature - Shrinking the accelerators and treatment room machines as well as model-based reimbursement decisions and pan-national referrals should decrease the cost of proton therapy and the scope of cancers treated.

Impact of spot charge inaccuracies in IMPT treatments

01 August 2017

A.C. Kraan, N. Depauw, B. Clasie, M. Giunta, T. Madden, Hanne M. Kooy - Medical Physics Volume 44, Issue 8 - Pencil-beam scanning in proton therapy is even more accurate than what would be medically necessary.

Fundamental Research as a Driver for Disruption, Presentation by Prof Steve Myers

23 June 2017

At its annual corporate event organised in Sardinia in 2017, Goetzpartners brought together personalities from all backgrounds. Prof Steve Myers, Executive Chairman of ADAM and Director of Advanced Oncotherapy plc, was invited to present the LIGHT Technology.

Director Talks meets Hans Van Celsing

10 April 2017

Following his appointment at Senior Independent Non-Executive Director, Hans von Celsing talks to DirectorsTalk about his past experience, the present and his thoughts on the future of the company.

LIGHT: A Linear Accelerator For Proton Therapy

01 October 2016

A. Degiovanni, P. Stabile, D. Ungaro (A.D.A.M. SA) - NAPAC2016, Chicago, IL, USA - A detailed presentation of our proton therapy system.

A(relatively) risky business: the link between prostatic radiotherapy and second malignancies

01 March 2016

The BMJ - Radiotherapy increases the probability of secondary malignancies in prostate cancer patients. Another argument for a more wide-spread use of proton therapy?

Ashya King proton beam cancer therapy 'causes fewer side effects'

01 January 2016

BBC News - Patient story about, how proton therapy is the better option in children's cancer.

Scientists put final pieces into place for seeing cancer with protons'

01 January 2016

Proton beam are not only useful in radiation therapy, but also as an imagining technique.

Ashya King goes back to school full time'

01 January 2016

The Guardian - Thanks to proton therapy treatment the little Ashya King recovered very fast.

Proton radiation therapy shows ongoing advancements throughout past quarter century'

01 July 2015

TMC news - A timeline of proton beam therapy development.

The Physics of Proton Therapy

01 March 2015

Wayne Newhauser & Rui Zhang - Physics in Medicine & Biology - Proton beam therapy explained by physicists.